Friday, May 05, 2006

More mercury and DHT explanations

Hi !

This is getting interesting... Here is excerpt from "Growth and Loss of Hair" by Richard L. De ViIIez, MD, Associate Professor, Division of Dermatology, University of Texas Health Science Center (this document can be found at www.regrowth.com)

Below one can find references to my implications. My theory: 1. Because DHT gene is not the culprit for hairloss, it might be that hairloss happens when DHT combines to cytosine (cytosine contains mercury) and since mercury is highly toxic, body attacks to it. 2. Hair contains lot of sulphur: mercury just loves to bind sulphur -> toxic keratin 3. Brain protein formation is disturbed by mercury (btw, latest research suggests that brain proteins could lead to cure of baldness (see www.regrowth.com) 4. Zinc is known antagonist for mercury (zinc also reduces DHT)

H! ere's references:

Aminoacid analysis of hair: "For synthesis of follicular proteins, the most important amino acids are those that contain sulfur i.e., predominantly cystine, because it forms stable disulfide bonds between keratin molecules. Table 2 indicates that cystine is the amino acid of highest concentration in fully formed bait."

Notice: Mercury (one gets from i.e. fish or amalgam) binds to sulphur (and consumes it lot)

"The DHT combines with a cytosol receptor to form a complex that enters the nucleus and joins with chromatin to initiate protein synthesis."

Next excerpt is from Medline (note: Zinc is mercury antagonist):

Biol Trace Elem Res 1994 Dec;46(3):229-45

Heavy metal intracellular balance and relationship with metallothionein induction in the gills of carp. After contamination by Ag, Cd, and Hg following pretreatment with Zn or not. !

Cosson RP

Service d'Ecotoxicologie, URA-1356-CNRS, Faculte de Pharmacie, Nantes, France.

Determination of metal levels (Cu, Zn, Cd, Ag, Hg) in soluble and insoluble fractions of gill homogenates has been performed after 7 d exposure of carp (Cyprinus carpio) to moderate concentrations of Cd, Ag, and Hg in water. Metallothionein levels have been quantified by polarographic method before and after contamination and a subsequent decontamination phase (7 d). The influence of pretreatment by zinc (7 d) has also been evaluated. Metallothionein level variations have been interpreted as having regard to interrelated flows of metal between subcellular fractions. Special interest has been focused on heat-stable compound (HSC)-bound heavy metal flows within the cytosol, taking in account that MT is the major component of these ligands. Our data showed differences between the ability of metals to bind cytosolic ligands and HSCs, and their respective potency for MT induction in gill. Regardless of pretreatment, mercury gave the high! est increase of gill MT, and after the decontamination MT level remained high compared to control. Cadmium and silver gave similar increases, but a significant difference with control appeared only after the decontamination step with silver, whereas 1 week of contamination was enough for cadmium. Our experimental conditions gave the following order of potency for MT induction in gill: Hg > > Cd > Ag

PMID: 7702978, UI: 95217623

Erik

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